​​Wetted Materials

Pump heads, check valve bodies, and tubing are made out of type 316 stainless steel or PEEK, depending on version ordered (NOTE: Titanium is also available, as well as other exotic materials like Hastelloy C.) Other common materials are synthetic ruby and sapphire (check valve internals and piston), UHMWPE (seals), PTFE (check valves), and PFA (pulse dampener diaphragm, if applicable).

Solvents with Harmful Effects

Except for PEEK pump heads, all portions of the pump that contact mobile phase are manufactured of type 316 stainless steel, ceramic, sapphire, ruby, or fluoropolymers. Some of these materials are extremely sensitive to acids (including some Lewis acids) and acid halides. Avoid using solvents that contain any amount of hydrochloric acid.
NOTE: THF and most solvents are only compatible with all-Stainless Steel systems. THF will attack PEEK.

Cole-Parmer Chemical Compatibility Guide

Some solvents to specifically avoid with PEEK are:

  • Aqua Regia (80% HCL, 20% HNO3)
  • Benzene Sulfonic Acid
  • Bromine
  • Carbolic Acid (Phenol)
  • Carbon Bisulfide
  • Carbon Disulfide
  • Chlorine Water
  • Chlorine, Anhydrous Liquid
  • Chromic Acid 10%
  • Chromic Acid 50%
  • Fluorine
  • Formic Acid
  • Hydrobromic Acid
  • Hydrofluoric Acid
  • Iodine
  • Nitric Acid
  • Phenol (Carbolic Acid)
  • Sulfuric Acid
  • Tetrahydrofuran (THF)
Some solvents to specifically avoid with 316 Stainless Steel are:

  • Aluminum Chloride 20%
  • Aluminum Fluoride
  • Aluminum Hydroxide
  • Ammonium Phosphate
  • Aniline Hydrochloride
  • Antimony Trichloride
  • Aqua Regia (80% HCL, 20% HNO3)
  • Aromatic Hydrocarbons
  • Benzonitrile
  • Bromine
  • Chloric Acid
  • Chlorine Water
  • Chlorine, Anhydrous Liquid
  • Copper Chloride
  • Copper Fluoborate
  • Ethyl Sulfate
  • Ferric Chloride
  • Ferrous Chloride
  • Hydrobromic Acid
  • Hydrochloric Acid
  • Hydrofluoric Acid
  • Hydrofluosilicic Acid
  • Iodine
  • Lead Sulfamate
  • Magnesium Chloride
  • Melamine
  • Mercuric Chloride (dilute)
  • Mercuric Cyanide
  • Nickel Chloride
  • Nitrating Acid
  • Pentane
  • Perchloric Acid
  • Phosphoric Acid
  • Plating Solutions
  • Sea Water
  • Silver Bromide
  • Sodium Bisulfate
  • Sodium Bromide
  • Sodium Fluoride
  • Sodium Hypoclorite
  • Sodium Sulfide
  • Stannic Chloride
  • Sulfur Chloride
  • Sulfur Trioxide
  • Sulfuric Acid
  • Tartaric Acid
  • Trichloroacetic Acid

This chemical compatibility information is taken from the Cole Parmer chemical compatibility database, which can be found at:  coleparmer.com/Chemical-Resistance

WARNING
The information in this chart has been supplied to Cole-Parmer by other reputable sources and is to be used ONLY as a guide in selecting equipment for appropriate chemical compatibility. Before permanent installation, test the equipment with the chemicals and under the specific conditions of your application.
Ratings of chemical behavior listed in this chart apply at a 48-hr exposure period. Cole-Parmer has no knowledge of possible effects beyond this period. Cole-Parmer does not warrant (neither express nor implied) that the information in this chart is accurate or complete or that any material is suitable for any purpose.
DANGER
Variations in chemical behavior during handling due to factors such as temperature, pressure, and concentrations can cause equipment to fail, even though it passed an initial test. SERIOUS INJURY MAY RESULT. Use suitable guards and/or personal protections when handling chemicals.

Scientific Systems Chemical Compatibility Resource

In addition to the above chemicals, the following is a link to chemical compatibility information gathered by Scientific Systems, Inc.

Resistance

  • E – Excellent
  • G – Good
  • F – Fair
  • N – Not Recommended
Material

  • PTFE – Polytetrafluoroethylene including of Teflon®
  • SS – Stainless Steel (316)
  • PE#1 – Convenional Polyethylene
  • PE#2 – Rigid Polyethylene
  • PP – Polypropylene
  • PVC – Polyvinylchloride
ChemicalPTFESSPE#1PE#2PPPVC
AcetaldehydeEEGGGG
AcetamideEEEEEN
Acetic Acid, 5%EEEEEE
Acetic Acid, 50%EEEEEE
AcetoneEEEEEE
Aluminum HydroxideEEEEEE
AmmoniaEEEEEE
Ammonium HydroxideEEEEEE
Ammonium OxalateEEEEEE
n-Amyl AcetateEEGEGF
Amyl ChlorideENFNN
AnilineEEEEGN
BenzaldehydeEEEEN
BenzeneEEFGGN
Benzoic Acid, Sat.EEEEEE
Benzyl AcetateEEEEF
Boric AcidEFEEEE
BromineENNFNG
BromobenzeneENFNF
n-Butyl AcetateEFGEGN
sec-Butyl AlcolholEEEEG
Butyric AcidEENFNG
Calcium HypochloriteEFEEEG
CarbazoleEEEEN
Carbon DisulfideEENNEN
Carbon TetrachlorideEGFGGG
ChlorineEGGGGE
Chloroacetic AcidEFEEEF
ChloroformEEFGGN
Chromic AcidEGEEEE
Citric AcidEEEEEG
CresolEENFEN
CyclohexaneEEGEGG
DecalinEGEGE
o-DichlorobenzeneEFFFG
p-DichlorobenzeneEFGEN
Diethyl BenzeneENFNN
Diethyl EtherENFNF
Diethyl KetoneEGGGN
Diethyl MalonateEEEEG
Dimethyl FormamideEEEEF
EtherEENFNF
Ethyl AcetateEEEEEF
Ethyl BenzeneEFGFN
Ethyl BenzoateEFGGN
Ethyl ButyrateEGGGN
Ethyl Chloride, LiquidEEFGFN
Ethyl CyanoacetateEEEENF
Ethyl LactateEEEEF
Ethylene ChlorideEEGGGN
Ethylene GlycolEEEEEE
Ethylene OxideEFGFF
FluorineGFGGN
Formic Acid, 50%EFEEEG
Formic Acid, 90-100%ENEEEF
Fuel OilEEFGEE
GasolineEEFGEG
GlycerineEEEEEE
n-HeptaneEEFGEF
HexaneEENGEG
Hydrocloric Acid, 1-5%ENEEEE
Hydrocloric Acid, 35%ENEEEG
Hydrocloric Acid, 4%ENEEEG
Hydrocloric Acid, 48%ENEEEG
HydrogenEEEEE
Hydrogen PeroxideEFEEEE
Isopropyl AcetateEGEGN
Isopropyl BenzeneEFGFN
KeroseneEEFGGE
Lactic Acid, 3%EGEEEG
Lactic Acid, 85%EFEEEG
Magnesium SaltsEGEEEE
Methoxyethyl OleateEEEEN
Methyl Ethyl KetoneEEEEEN
Methyl Isobutyl KetoneEEGEGN
Methyl Propyl KetoneEGEGN
Methylene ChlorideEEFGFN
Nitric Acid, 50%EGEGGG
Nitric Acid, 70%ENEGGF
NitrobenzeneEEFGFN
n-OctaneEEEEF
Orange OilEFGGF
Perchloric AcidEGGGG
PerchloroethyleneEENNNN
Phenol, CrystalsEEGGGF
Phosphoric Acid, 1-5%EEEEEE
Phosphoric Acid, 85%EGEEEE
Potassium HydroxideEGEEEE
Propane GasEENFNE
Propylene GlycolEEEEEF
Propylene OxideEEEEF
ResorcinolEEEEF
SalicylaldehydeEEEEF
Sulfuric Acid, 1-6%EFEEEE
Sulfuric Acid, 20%ENEEEE
Sulfuric Acid, 60%ENEEEE
Sulfuric Acid, 98%ENEEEN
Sulfur Dioxide, Liq.EENFNF
Sulfur SaltsEEFGFN
Tartaric AcidEGEEEE
TetrahydrofuranEEFGGN
Thionyl ChlorideENNNN
TolueneEEFGGF
TrichloroethaneEENFNN
TrichloroethyleneEENFNN
TurpentineEEFGGG
Vinylidene ChlorideENFNN
XyleneEEGGFN
Zinc Salts / StearateEGEEEE
Resistance at 20°CPEEKPEPPPPSFEPEFTEPFAPTFE
AcetaldehydeAAA
Acetic Acid (20%)AAAAAAAA
Acetic Acid (80%)AAAAAAA
Acetic Acid (glacial)AAAAAAAA
AcetoneABAAAAAA
AcetonitrileAAAAAA
Acrylic AcidAAAA
Ammonia, AnhydrousAAAA
Ammonia (10%)ABAAAAAA
Ammonia (liquid)BAAA
Ammonia HydroxideAAAAAAAA
Aqua RegiaCCAA
Aromatic HydrocarbonsABCAAA
BenzeneABCAAAAA
Benzoic AcidAAAA
BenzaldehydeAAAA
Bromine / DibromoethaneCCAA
Bromine (dry)CCAA
Bromine (wet)CCAA
Boric AcidAAAA
ButanolAAAAAAAA
Calcium HydroxideAAAA
Carbon TetrachlorideAAAA
Chlorine (gas)ACAA
Chlorine (liquid)CCAA
Chloroacetic AcidABBAAAAA
ChlorobenzeneAAAA
ChloroformABBAAAAA
CyclohexanoneACCAAAAA
DiethylamineACAAAAA
DiethyletherAAAA
DiethylformamideAAAAAAAA
DioxaneAAAAA
EthanolABAAAAAA
EtherABCAAAAA
Ethyl AcetateABAAAAAA
Ethylene ChlorideBBAAAAA
Ethylene GlycolBBAAAAA
HeptaneABBAAAAA
HexaneABBAAAAA
Hydrobromic Acid (20%)CBBAAAA
Hydrobromic Acid (100%)CBAAAAA
Hydrocloric Acid (20%)AABCAAAA
Hydrocloric Acid (100%)ABCAAAA
Hydrofluoric Acid (20%)AAAAAAA
Hydrofluoric Acid (100%)CBCAAAA
Hydrogen Peroxide (10%)AAAAAAAA
Hydrogen Peroxide (50%)ABBAAAA
Hydrogen Peroxide (100%)ABBCAAA
KetonesABBAAAA
Iso-OctaneAAAAAA
IsopropanolAAAAAAA
Isopropyl EtherABAAA
MethanolAAAAAAAA
Methyl DichlorideCAA
Methyl EthylketoneABBAAAAA
Methyl ChlorideBBBAAAAA
Nitric Acid (20%)ABACAAAA
Nitric Acid (100%)CBCCAAAA
PentaneACCAAA
Perchloric AcidABBBBA
Phenol (dilute)AAAA
Phenol (concentrated)CAAA
Phosphoric Acid (40%)AAAAAAAA
Phosphoric Acid (100%)ABAAAAAA
Potassium Hydroxide (dilute)AAAA
Potassium Hydroxide (70%)AAAA
PropanolAAA
PyridineABAAAAAA
TetrahydrofuranBBBAAAAA
TolueneABBAAAAA
Trichloroacetic AcidAAAAAAAA
TrichloroethaneABAAA
TrichloroethyleneAAAA
TriethylamineCAAAA
Sodium Hydroxide (20%)AAAAAAAA
Sodium Hydroxide (80%)ABAAAAA
Sulfuric Acid (40%)AAAAAAAA
Sulfuric Acid (75%)CAAAAAAA
Sulfuric Acid (100%)CBBAAAAA
WaterAAAAAAAA
Water (distilled)AAAAAAAA
XyleneAAAA

Additional Comments

Some users of HPLC systems have observed that Chloroform and Carbon Tetrachloride slowly decompose to liberate hydrochloric acid, which, as noted above, attacks stainless steel. Do not leave these solvents in the systems for a prolonged period.

It is also recommended to avoid ammonium hydroxide. Although ammonium hydroxide will not harm the pump itself, it is likely to damage the stator and rotor in injection valves.

Fluorinated polymers like PTFE (polytetrafluoroethylene), and PFA (perfluoroalkoxy) are inert to almost all common acids, bases, and solvents. They have limited life time in the presence of Hexafluoroisopropanol (HFIP). To ensure the longest possible life with HFIP, it is best to dedicate a particular pump to this solvent, not to switch solvents, and not to let dry out the internal fluid path, including the pulse dampener.

On a final note, any chemical resistance is likely to be a function of the time and temperature of exposure, and also if there are any mechanical stresses on the part. If chemical compatibility information cannot be found for a specific chemical product, it is recommended that customers test their product with the pump and fluid path in the actual application to ensure appropriate chemical resistance.